Amniotic membrane has found its use in diverse ophthalmological conditions. Persistent epithelial defects unresponsive to medical treatment, show a good response with amniotic membrane transplantation. It has been used as an alternative to conjunctival autograft during the removal of pterygium, in cases where bulbar conjunctiva needs to be preserved for further surgeries.

Large conjunctival defects as occurring after removal of conjunctival lesions and in cases of recurrent pterygium with symblepheron are successfully bridged by amniotic membrane. In conditions where stem cells are deficient or there is associated dry eye (as in chemical burns and Steven-Johnson syndrom) AMT is combined with limbal auto/ allograft and intensive dry eye therapy.

Fujishima et. al. recently used amniotic membrane in filtration procedures supplemented with mitomycin-c to inhibit scarring and promote filtration.

Bundez et. al. reported favorable results of AMT for revision of leaking blebs.

AMT can be considered an effective alternative for treating severe neurotrophic corneal ulcer.